Gain-of-Function Variant in Spleen Tyrosine Kinase Regulates Macrophage Migration and Functions to Promote Intestinal Inflammation
Gain-of-function variant in <i>SYK</i> may contribute to the pathogenesis of pediatric inflammatory bowel diseases by promoting macrophage migration, phagocytosis, ROS production and activation of NLRP3 inflammasomes.
Authors
- Ying Huang (ORCID: https://orcid.org/0000-0002-4931-4006)
- Chenguang He (ORCID: https://orcid.org/0000-0002-3683-9401)
- Zhiyang Zeng (ORCID: https://orcid.org/0000-0002-0235-1352)
- Yanqiu Wang (ORCID: https://orcid.org/0000-0002-5488-8792)
- Lin Wang (ORCID: https://orcid.org/0000-0002-1530-6542)
- Ye Yang (ORCID: https://orcid.org/0000-0003-2314-4579)
Institutions
- Xian Central Hospital (CN)
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/jir.s488901
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Shanghai Rising-Star Program
- National Key Research and Development Program of China