The epidermal growth factor receptor inhibitor gefitinib enhances in vitro and in vivo sensory axon regeneration and functional recovery following transection in a mouse median nerve injury model
This study provides data supporting the role of EGFR as a negative regulator of sensory but not motor neuron regeneration. Further, it demonstrates versatile potential uses of existing pharmaceuticals.
Authors
- Anne‐Marie Crotty
- Max Topley (ORCID: https://orcid.org/0009-0002-1050-4360)
- J. Michael Hendry (ORCID: https://orcid.org/0009-0004-0108-9120)
- Michael D. Kawaja
- Payton Sparks (ORCID: https://orcid.org/0009-0001-1230-0997)
Institutions
- Queen's University (CA)
- Kingston Health Sciences Centre (CA)
- Marian University - Indiana (US)
Publication Details
- Journal
- Muscle & Nerve
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1002/mus.28291
- Citations
- 2
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.54