Dual effects of <i>DLG5</i> (disks large homolog 5 gene) modulation on chemotherapy‐induced thrombocytopenia and nausea/vomiting via the hippo signalling pathway
We identified a series of germline mutations associated with susceptibility to CIT and CINV. Of particular interest, we demonstrated that induced and suppressed DLG5 expression is respectively related to CIT and CINV. These findings shed light on the involvement of the hippo signalling pathway and DLG5 in the development of CRAEs, providing valuable insights into potential targets for therapeutic interventions.
Authors
- Shi Qiu (ORCID: https://orcid.org/0000-0003-4304-222X)
- Wansheng Chen (ORCID: https://orcid.org/0000-0002-0025-1315)
- Zhipeng Wang (ORCID: https://orcid.org/0000-0002-7964-9288)
- Shouhong Gao
- Yunsheng Chai (ORCID: https://orcid.org/0000-0002-7194-5699)
- Tao Yan (ORCID: https://orcid.org/0000-0002-2464-2361)
- Mingming Li (ORCID: https://orcid.org/0000-0003-0621-6227)
- Xia Tao
- Rong Wang (ORCID: https://orcid.org/0000-0002-2184-6414)
Institutions
- Second Military Medical University (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Changzheng Hospital (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1111/bph.17391
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China