Community intervention of a single-dose or 2-dose regimen of bivalent human papillomavirus vaccine in schoolgirls in Thailand: vaccine effectiveness 2 years and 4 years after vaccination
Our study demonstrated that both single-dose and 2-dose HPV vaccination significantly decreased HPV-16/18 point prevalence 2 years and 4 years after vaccination. Crude vaccine effectiveness at 4 years after vaccination was greater than 90% for both the single-dose and 2-dose regimens; the single-dose regimen was not inferior to the 2-dose regimen. These data show that a single dose of HPV vaccine provides high levels of protection when administered to schoolgirls younger than 15 years of age.
Authors
- Sunju Park (ORCID: https://orcid.org/0000-0001-5540-5302)
- Pornjarim Nilyanimit (ORCID: https://orcid.org/0000-0003-2250-0017)
- Suchada Jiamsiri
- Worrawan Klinsupa
- Jinae Lee (ORCID: https://orcid.org/0000-0003-4280-8131)
- Sompong Vongpunsawad (ORCID: https://orcid.org/0000-0001-7520-8728)
- Hyeong-Won Seo
- Chawetsan Namwat
- Lauri E. Markowitz (ORCID: https://orcid.org/0000-0002-2480-9520)
- Jean‐Louis Excler (ORCID: https://orcid.org/0000-0002-6462-5101)
- Yun Chon (ORCID: https://orcid.org/0000-0002-3561-6345)
- Julia Lynch (ORCID: https://orcid.org/0000-0001-8048-5340)
- Joshua N. Sampson (ORCID: https://orcid.org/0000-0003-2875-3365)
- Elizabeth R. Unger (ORCID: https://orcid.org/0000-0002-2925-5635)
- Patummal Silaporn
- Chulwoo Rhee (ORCID: https://orcid.org/0000-0001-6868-7302)
- Nakorn Premsri
- Gitika Panicker
- Nimesh Poudyal (ORCID: https://orcid.org/0000-0002-4156-7017)
- Deok-Ryun Kim
- Hyeon Seon Ahn (ORCID: https://orcid.org/0009-0004-1534-1323)
- Yong Poovorawan (ORCID: https://orcid.org/0000-0002-2337-6807)
- Supachai Rerks‐Ngarm
Institutions
- Centers for Disease Control and Prevention (US)
- National Institutes of Health (US)
- International Vaccine Institute (KR)
- Chulalongkorn University (TH)
- National Cancer Institute (US)
Publication Details
- Journal
- JNCI Monographs
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1093/jncimonographs/lgae036
- Citations
- 1
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Bill and Melinda Gates Foundation