EVALUATION OF THE FUNCTIONAL STATE OF KIDNEYS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION BASED ON THE DETERMINATION OF CREATININE AND CYSTATIN C LEVELS

Aim – to evaluate the functional state of kidneys, glomerular filtration rate based on the determination of creatinine and Cystatin C in STEMI patients undergoing urgent revascularization.Methods and materials. The study included 286 patients with acute myocardial infarction and ST-elevation myocardial infarction (STEMI). Among the examined persons, 202 (70.6%) were men and 84 (29.4%) were women, with an average age of (62.8±9.8) years.Research results. The GFR calculated by the CKD-EPI formula in the examined group of STEMI patients ranged from 15.6 to 87.4 and averaged 51.0±14.3 ml/min∙m2.7. The value of the calculated GFR according to the CKD-EPI Cystatin C formula ranged from 11.1 to 88.1 and averaged 45.7±13.7 ml/min/1.73 m2. The non-parametric Spearman rank correlation analysis showed a high direct correlation between the values of GFR calculated by different formulas (CKD-EPI and CKD-EPI Cystatin C) - R=0.81; p<0.0001. Using the linear regression method, a formula was derived for the conditional calculation of GFR value according to CKD-EPI Cystatin C = 4.15 + GFR value according to CKD-EPI 0.814. Regression coefficient R2 = 0.84 (Fisher's correlation coefficient - F = 728.34 at the proper level = 1.28), p < 0.000001.Conclusions. Determination of GFR based on Cystatin C demonstrates lower rates in both men and women. A decrease in estimated GFR was related to older age and female gender.