OGC O01 - Stomach Cancer Elective Surgery Morbidity and Mortality at 90-Days (HOLD Study): A Prospective, International Collaborative Cohort Study

Abstract Background Data on multinational 90-day mortality and morbidity rates after surgery for gastric cancer is limited in the literature. This study aimed to understand the 90-day mortality and morbidity outcomes according to GASTRODATA Registry for elective gastric cancer surgery patients and identify risk factors. Method We conducted an international prospective study on ≥18 years patients undergoing elective surgery for gastric cancer with curative intent from 01 April 2022 to 30 September 2022. Known metastatic disease, concurrent secondary cancers, gastrointestinal stromal tumour (GIST) and Siewert type I/II oesophagogastric junction malignancies were excluded. Univariate and multivariate logistic regression was used to identify variables associated to 90-day outcome. Results 380 collaborators from 47 countries submitted data on 1538 patients. Mean age was 64.2 years and 58.5% were males. 90-day morbidity rate was 38.2% (n=587) and mortality rate was 2.9% (n=45). Pre-operative higher CCI or ASA score, pre-operative weight loss >10%, and surgical determinants such as type of gastric resection, positive specimen margin, number of harvested lymph nodes, longer surgery duration and post operative pathological IV staging (p value<0.05) were identified as predictors of postoperative severe complications and mortality. Conclusion Elective gastric cancer surgery has a 90-day morbidity of 38.2% and 90-day mortality of 2.9%, globally. This study identified several factors associated with higher morbidity and exemplified the importance of a unified language on surgical morbidity, pre-habilitation and ongoing audits to enhance patient outcomes.

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Journal
British journal of surgery
Published
2024-11-01
DOI
https://doi.org/10.1093/bjs/znae271.311
Primary Topic
Gastric Cancer Management and Outcomes
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article
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article

OGC O01 - Stomach Cancer Elective Surgery Morbidity and Mortality at 90-Days (HOLD Study): A Prospective, International Collaborative Cohort Study

Khayry Al‐Shami, Georgios Ioannis Verras, José Pedro Barbosa, Christos Chouliaras et al.
British journal of surgery
Gastric Cancer Management and Outcomes
article

OGC O01 - Stomach Cancer Elective Surgery Morbidity and Mortality at 90-Days (HOLD Study): A Prospective, International Collaborative Cohort Study

Khayry Al‐Shami, Georgios Ioannis Verras, José Pedro Barbosa, Christos Chouliaras, Ulaş Aday, Suraj Surendran, Takahiro Kinoshita, Server Sezgin Uludağ, Pedro Serralheiro, А. К. Кострыгин, Javier Ithurralde-Argerich, Jurij Aleš Košir, Merve Tokoçin, Francesk Mulita, D. D. Sobolev, Giuseppe Palomba, Rishi Singhal, Jan Grosek, Giorgio Ercolani, Ibtissam Bin Khalid, Rostislav Pavlov, Kamal Kumar Mahawar, Myla Yacob, Kirill Vovin, Maciej S. Walędziak, Viktoria Davletshina, C Neves-Marques, Susan Vaz, Laurent Genser, Andrea Muratore, Serhat Meric, Azize Saroglu, Inian Samarasam, Amaar Aamery, Pasquale Cianci, Elgun Samadov, Daiki Terajima, Anaya Gupte, Ahmed K. Awad, Zdenko Boras, Martín Andrada, Marta Fragoso, Massimiliano Veroux, Arturan İbrahimli, İsmail Hasırcı, Giovanna Pavone, Cara Baker, Omeed Rasheed, Fabrizio D’Acapito, Shahid Khattak, Aamir Ali Syed, Tania Triantafyllou, André Caiado, A. Menasria, Athanasios Syllaios, Fatima Tu Zahara, Zbigniew Lorenc, Sílvia Guerrero, Tevfik Kıvılcım Uprak, Taryel Omarov, N.M. Abdulkhakimov, Elif Çolak, Mohamed Abouelazayem, Amine Souadka, V. M. Khomyakov, Can Ertug Cayirci, Alex Boddy, Anouar Remini, Abdul Wahid Anwer, Kelvin Voon, Ana C. Almeida, E. S. Drozdov, Claire Donohue, Beatriz Costeira, José Thomas Machado de Sousa, Negine Paul, Ana Melo, Aysuna Galandarova, Alessandro Martinino, Massimo Framarini, Efstratia Baili, Giacomo Calini, Turgut Dönmez, Mehmet Karabulut, Ergin Erginöz, Khurram Khan, Faris Alhajami, Essam Eldien Abuobaida, Hassan Ahmed, Wiktor Krawczyk, M Correia, S. Ferreira, Elio Sanchez, Geoffrey Yuet Mun Wong, Massimo Vecchiato, Fabiana Sousa, Andrey Ryabov, Dimitrios Schizas, Ricardo David Maldonado, Ashraf Bakri, Muhammed Salih Süer, Esin Cinal, Oussama Baraket, Akshant Pathak, Jorge Santos, Gadi Marom, Alexander Zacharenko, Sarnai Erdene, Mohammad Badr, Oguzhan Simsek, Y K S Vish, Ilya Gorohov, Jorge Milhomem, Raul Pinillla, Juan Pablo Scarano
article en

Abstract

Abstract Background Data on multinational 90-day mortality and morbidity rates after surgery for gastric cancer is limited in the literature. This study aimed to understand the 90-day mortality and morbidity outcomes according to GASTRODATA Registry for elective gastric cancer surgery patients and identify risk factors. Method We conducted an international prospective study on ≥18 years patients undergoing elective surgery for gastric cancer with curative intent from 01 April 2022 to 30 September 2022. Known metastatic disease, concurrent secondary cancers, gastrointestinal stromal tumour (GIST) and Siewert type I/II oesophagogastric junction malignancies were excluded. Univariate and multivariate logistic regression was used to identify variables associated to 90-day outcome. Results 380 collaborators from 47 countries submitted data on 1538 patients. Mean age was 64.2 years and 58.5% were males. 90-day morbidity rate was 38.2% (n=587) and mortality rate was 2.9% (n=45). Pre-operative higher CCI or ASA score, pre-operative weight loss >10%, and surgical determinants such as type of gastric resection, positive specimen margin, number of harvested lymph nodes, longer surgery duration and post operative pathological IV staging (p value<0.05) were identified as predictors of postoperative severe complications and mortality. Conclusion Elective gastric cancer surgery has a 90-day morbidity of 38.2% and 90-day mortality of 2.9%, globally. This study identified several factors associated with higher morbidity and exemplified the importance of a unified language on surgical morbidity, pre-habilitation and ongoing audits to enhance patient outcomes.

British journal of surgeryVol. 111(Supplement_9)
University of Foggia (IT), Ain Shams University (EG), Latakia University (SY), Dicle University (TR), Mohammed V University (MA), National Academy of Medicine (US), University of Udine (IT), University Hospitals Birmingham NHS Foundation Trust (GB), Cairo University (EG), Immanuel Kant Baltic Federal University (RU), Medical University of Silesia (PL), University of Health Science (KH), St Petersburg University (RU), Christian Medical College, Vellore (IN), Trakia University (BG), Universidade do Porto (PT), Azerbaijan Medical University (AZ), Siberian State Medical University (RU), Hebrew University of Jerusalem (IL), Guy's and St Thomas' NHS Foundation Trust (GB), National and Kapodistrian University of Athens (GR), Trinity College Dublin (IE), First Pavlov State Medical University of St. Petersburg (RU), Royal North Shore Hospital (AU), James Cook University Hospital (GB), Royal London Hospital (GB), Ljubljana University Medical Centre (SI), Cancer Institute (WIA) (IN), General University Hospital of Patras (GR), Hospitais da Universidade de Coimbra (PT), University Hospitals of Leicester NHS Trust (GB), University Hospitals Coventry and Warwickshire NHS Trust (GB), Hospital de São João (PT), National Ribat University (SD), Universidad Nacional de Colombia (CO), University of Catania (IT), University of Illinois Chicago (US), Sorbonne Université (FR), Patel Hospital (IN), Mongolian National University of Medical Sciences (MN), Ospedale Civile Edoardo Agnelli (IT), Assistance Publique – Hôpitaux de Paris (FR), Hospital Prof. Dr. Fernando Fonseca (PT), Christian Medical College (IN), Unidade Local de Saúde de Trás-os-Montes e Alto Douro (PT), Istanbul University-Cerrahpaşa (TR), Bağcılar Eğitim ve Araştırma Hastanesi (TR), Samsun University (TR), Instituto Nacional de Cancerología (CO), National Institute of Oncology (HU), Advocate Illinois Masonic Medical Center (US), Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi (TR), Ospedale G.B. Morgagni - L.Pierantoni (IT), Hospital de Santo António (PT), Shaukat Khanum Memorial Cancer Hospital and Research Center (PK), Klinički bolnički centar Osijek (HR), Athens Medical Center (GR), Instituto de Gastroenterología (CU), South Tyneside and Sunderland NHS Foundation Trust (GB), Ospedale L. Bonomo (IT), P.A. Hertzen Moscow Oncology Research Institute (RU), National Cancer Center Hospital East (JP), Delhi State Cancer Institute (IN), Hospital Privado (AR), Hospital Universitario San Ignacio (CO), Centro Hospitalar do Porto (PT), Hospital Piñero (AR), Hopital Universitaire Habib Bourguiba (TN), Hippocration General Hospital (GR), University College London (GB), University of Sunderland (GB), Hacettepe University (TR), University of Naples Federico II (IT), University of Glasgow (GB), Universidade Nova de Lisboa (PT), Damascus University (SY)
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Openalex Percentile: Top 62%
Gastric Cancer Management and Outcomes
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