Gene expression screening and cell factory engineering for enhancing echinocandin B production in Aspergillus nidulans NRRL8112
This study, for the first time, revealed the regulatory mechanism of ECB biosynthesis and harnessed genetic engineering for the development of an efficient ECB-producing strain.
Authors
- Yanling Li (ORCID: https://orcid.org/0000-0002-3632-6294)
- You-Chu Ma (ORCID: https://orcid.org/0000-0001-7102-9570)
- Yan Fu (ORCID: https://orcid.org/0000-0002-4942-159X)
- Rui Zhu (ORCID: https://orcid.org/0000-0002-9008-9875)
- Yuan Tian (ORCID: https://orcid.org/0000-0001-7782-8613)
- Shumin Wang (ORCID: https://orcid.org/0000-0003-0035-3677)
- Rui Li (ORCID: https://orcid.org/0000-0001-7698-6927)
- Fanglong Zhao (ORCID: https://orcid.org/0000-0002-4180-5951)
- Rui Zhang (ORCID: https://orcid.org/0000-0002-1360-2452)
Institutions
- Shandong First Medical University (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s12934-024-02577-w
- Citations
- 8
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 3.58
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Shandong First Medical University