Immunomodulatory metabolites in <scp>I</scp> g <scp>E</scp> ‐mediated food allergy and oral immunotherapy outcomes based on metabolomic profiling
We observed distinct profiles of bile acids, histidines, and eicosanoids that vary among patients with food allergy, over time on OIT and between SU and TD. Participants with SU had higher levels of metabolites such as lithocholate and urocanic acid, which have immunomodulatory roles in key T-cell subsets, suggesting potential mechanisms of tolerance in immunotherapy.
Authors
- Neal Patrick Smith (ORCID: https://orcid.org/0000-0003-1394-3158)
- Supinda Bunyavanich (ORCID: https://orcid.org/0000-0001-6108-439X)
- Jessica Ann Lasky-Su (ORCID: https://orcid.org/0000-0001-6236-4705)
- Jennifer N. Styles (ORCID: https://orcid.org/0000-0001-6777-1334)
- Juan C. Celedón (ORCID: https://orcid.org/0000-0002-6139-5320)
- Rachel S. Kelly (ORCID: https://orcid.org/0000-0003-3023-1822)
- Clary B. Clish (ORCID: https://orcid.org/0000-0001-8259-9245)
- Erin Baker (ORCID: https://orcid.org/0000-0001-5246-2213)
- Yamini V. Virkud (ORCID: https://orcid.org/0000-0001-7328-7215)
- Scott T. Weiss (ORCID: https://orcid.org/0000-0001-7196-303X)
- Wayne G. Shreffler (ORCID: https://orcid.org/0000-0001-6465-137X)
- Craig E. Wheelock (ORCID: https://orcid.org/0000-0002-8113-0653)
- Augusto A. Litonjua (ORCID: https://orcid.org/0000-0003-0422-5875)
- Bert Ruiter (ORCID: https://orcid.org/0000-0003-3945-3202)
- Sarita U. Patil
Institutions
- Broad Institute (US)
- University of North Carolina at Chapel Hill (US)
- Brigham and Women's Hospital (US)
- Karolinska University Hospital (SE)
- Harvard University (US)
- Karolinska Institutet (SE)
- Massachusetts General Hospital (US)
- Children's Hospital of Pittsburgh (US)
- University of Pittsburgh Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Pediatric Allergy and Immunology
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1111/pai.14267
- Citations
- 11
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.59
Funders
- Harvard Catalyst
- Hjärt-Lungfonden
- National Institutes of Health
- American Academy of Allergy, Asthma and Immunology Foundation
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases
- National Institute of Environmental Health Sciences
- National Center for Research Resources
- National Center for Advancing Translational Sciences