Pyogenic granuloma and its relation to Human Papilloma virus

Introduction: Although many HPVs are harmless and even beneficial members of healthy tissue's microbiota, HR-HPV infection, especially when left untreated for an extended period of time, raises the risk of invasive malignancy. A benign vascular tumor known as a pyogenic granuloma (PG) often develops in the skin and other mucous membranes. [1] Methods: Participants were twenty patients seen over the course of six months at the Dermatology Outpatient Clinic of Minia University Hospital for vascular acral tumors. The use of consensus primers in polymerase chain reaction (PCR) amplification allowed for the detection of HPV (My09, My11). Amplifying a housekeeping gene at 268 bp ensured that the amplified DNA was intact. Results: Proliferative HPV particles were detected in just one skin biopsy out of twenty pyogenic granuloma patients. Conclusion: In this study we found that there is no relation between HPV and PG. Further studies are suggested to assess the possibility of relation between HPV and other skin tumors.