Associations between sex and lifestyle activities with cognitive reserve in mid-life adults with genetic risk for Alzheimer’s disease
Our findings suggest that occupational attainment in mid-life contributes to cognitive reserve against inherited risk of dementia in females, but not males. They highlight the need for high precision approaches that consider biological sex and APOE4 carrier status to inform Alzheimer's disease prevention strategies and clinical trials.
Authors
- Ivan Koychev (ORCID: https://orcid.org/0000-0001-6813-8493)
- John T. O’Brien (ORCID: https://orcid.org/0000-0002-0837-5080)
- Paresh Malhotra (ORCID: https://orcid.org/0000-0002-1897-0780)
- Siobhán Hutchinson (ORCID: https://orcid.org/0000-0002-6624-4142)
- Graciela Muñiz‐Terrera (ORCID: https://orcid.org/0000-0002-4516-0337)
- BRIAN A. LAWLOR (ORCID: https://orcid.org/0000-0002-5012-2116)
- David Robinson (ORCID: https://orcid.org/0000-0003-3504-5981)
- Karen A. Ritchie (ORCID: https://orcid.org/0000-0002-0688-8982)
- Lorina Naçi (ORCID: https://orcid.org/0000-0001-9630-3978)
- Feng Deng (ORCID: https://orcid.org/0000-0002-8596-1518)
- Qing Qi (ORCID: https://orcid.org/0000-0001-9347-3525)
- Rebecca Sammon
Institutions
- Inserm (FR)
- Trinity College Dublin (IE)
- University of Cambridge (GB)
- University of Oxford (GB)
- Ohio University (US)
- UK Dementia Research Institute (GB)
- Institute for Neurosciences of Montpellier (FR)
- St. James's Hospital (IE)
- Global Brain Health Institute (US)
- Imperial College London (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s13195-024-01610-9
- Citations
- 4
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.54
Funders
- National Institute for Health and Care Research