Cas9/guide RNA-based gene-drive dynamics following introduction and introgression into diverse anopheline mosquito genetic backgrounds
These findings support the conclusion that the AgNosCd-1 drive system is robust and has high drive inheritance and gene conversion efficiency accompanied by low NHEJ mutation rates in diverse An. gambiae s.l. laboratory strains.
Authors
- Marc Crepeau (ORCID: https://orcid.org/0000-0002-3639-3921)
- Rebeca Carballar‐Lejarazú (ORCID: https://orcid.org/0000-0002-9338-8774)
- Kiona Parker (ORCID: https://orcid.org/0000-0003-1553-8869)
- Thai Binh Pham (ORCID: https://orcid.org/0000-0001-7661-0495)
- Anthony Amade James (ORCID: https://orcid.org/0000-0001-5577-3308)
- Taylor Tushar (ORCID: https://orcid.org/0000-0001-6982-3249)
- Gregory Charles Lanzaro (ORCID: https://orcid.org/0000-0003-1190-9810)
Institutions
- University of California, Irvine (US)
- University of California, Davis (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s12864-024-10977-w
- Citations
- 6
- Primary Topic
- Insect Resistance and Genetics
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Bill and Melinda Gates Foundation
- Open Philanthropy Project
- National Institutes of Health
- University of California, Irvine
- National Institute of Allergy and Infectious Diseases