Transcriptomic Analysis of the Amygdala in Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder Reveals Differentially Altered Metabolic Pathways
Our findings suggest metabolic pathways, including downregulation of energy metabolism pathways in SCZ and upregulation of energy metabolism pathways in MDD, are uniquely altered in the amygdala in these disorders, which may impact approaches for therapeutic strategies.
Authors
- Eric J. Vallender (ORCID: https://orcid.org/0000-0003-3506-0540)
- Sinead M. O’Donovan (ORCID: https://orcid.org/0000-0003-3172-4952)
- Mahmoud Ali Eladawi (ORCID: https://orcid.org/0000-0003-1383-834X)
- Robert E. McCullumsmith (ORCID: https://orcid.org/0000-0001-6921-7150)
- Michael R. Garrett (ORCID: https://orcid.org/0000-0001-5234-7928)
- Jake Valeri
- Barbara Gisabella (ORCID: https://orcid.org/0000-0002-0072-790X)
- Harry Pantazopoulos (ORCID: https://orcid.org/0000-0002-8905-8377)
- Xiaolu Zhang (ORCID: https://orcid.org/0000-0002-9449-2047)
Institutions
- University of Limerick (IE)
- University of Mississippi Medical Center (US)
- Louisiana State University Health Sciences Center Shreveport (US)
- University of Toledo (US)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2024-10-23
- DOI
- https://doi.org/10.1093/schbul/sbae193
- Citations
- 7
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Brain Research Foundation
- American Foundation for Suicide Prevention
- Stanley Medical Research Institute
- National Institute of General Medical Sciences