Transplanted deep-layer cortical neuroblasts integrate into host neural circuits and alleviate motor defects in hypoxic-ischemic encephalopathy injured mice
Transplanted hESCs derived cortical neuroblasts survive, project to endogenous targets, and integrate into host cortical neural circuits to rescue animal behavior in the HIE-injured brain without graft overgrowth, providing a novel and safe cell replacement strategy for the future treatment of HIE.
Authors
- Wenhao Zhou (ORCID: https://orcid.org/0000-0001-8956-7238)
- Yuejun Chen (ORCID: https://orcid.org/0000-0002-4625-2604)
- Hui He (ORCID: https://orcid.org/0000-0002-3794-8677)
- Mengnan Wu
- Xiaoli Ji (ORCID: https://orcid.org/0000-0001-9888-0189)
- Ban Feng
- Yuan Li (ORCID: https://orcid.org/0000-0003-4335-1612)
- Yingying Zhou (ORCID: https://orcid.org/0000-0002-0496-2923)
- Qian Cheng (ORCID: https://orcid.org/0000-0003-3621-5743)
- Xingsheng Peng
- Man Xiong (ORCID: https://orcid.org/0000-0003-4948-9495)
- Yuan Xu
Institutions
- Chinese Academy of Sciences (CN)
- Fudan University (CN)
- Center for Excellence in Brain Science and Intelligence Technology (CN)
- Children's Hospital of Fudan University (CN)
- State Key Laboratory of Medical Neurobiology
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s13287-024-04049-9
- Citations
- 3
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.33
Funders
- National Natural Science Foundation of China
- Fudan University
- Special Funds for the Basic Research and Development Program in the Central Non-profit Research Institutesof China
- Program of Shanghai Academic Research Leader