Lactylation of Hdac1 regulated by Ldh prevents the pluripotent-to-2C state conversion
In summary, our study reveals a mechanistic link between cellular metabolism and pluripotency regulation through protein lactylation. Our research is the first time to reveal that quantitative lactylome analysis in mouse ESCs. We found that lactylated Hdac1 promotes its binding at 2C genes and enhances its deacetylase activity, thus facilitating the removal of H3K27ac and the silencing of 2C genes.
Authors
- Lingyi Chen (ORCID: https://orcid.org/0000-0002-3695-3407)
- Xiaoling Du (ORCID: https://orcid.org/0000-0001-7857-1688)
- Qingye Zhang (ORCID: https://orcid.org/0000-0002-9596-590X)
- Shanshan Nai (ORCID: https://orcid.org/0009-0005-9959-5300)
- Lingling Wang (ORCID: https://orcid.org/0000-0002-3412-1447)
- Nannan Zhao (ORCID: https://orcid.org/0000-0002-0488-1066)
- Qiman Dong
- Xiaoqiong Yang
Institutions
- Nankai University (CN)
- State Key Laboratory of Medicinal Chemical Biology
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s13287-024-04027-1
- Citations
- 9
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.95
Funders
- National Key Research and Development Program of China