Exposure to particulate matter (PM2.5) weakens corneal defense by downregulating thrombospondin-1 and tight junction proteins
PM<sub>2.5</sub> exposure leads to corneal epithelium damage by disrupting tight junction proteins and THBS1 expression. These findings provide insight into potential pathways for PM<sub>2.5</sub>-induced ocular toxicity and underscore the need for protective strategies against such environmental pollutants.
Authors
- Chunchun Hu (ORCID: https://orcid.org/0009-0002-3908-7548)
- Maomao Song
- Xinghuai Sun
- Liangliang Niu (ORCID: https://orcid.org/0009-0005-0481-3206)
- Rui Jiang (ORCID: https://orcid.org/0000-0003-3929-0570)
- Yuan Lei (ORCID: https://orcid.org/0000-0001-5651-0948)
- Binghui Liu (ORCID: https://orcid.org/0000-0003-2542-4099)
- Huan Xu (ORCID: https://orcid.org/0009-0001-7039-4469)
- Jiamin Liu (ORCID: https://orcid.org/0000-0003-0118-4852)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Eye & ENT Hospital of Fudan University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1016/j.ecoenv.2024.117276
- Citations
- 6
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.48