HISTOPATHOLOGICAL SPECTRUM OF WHIPPLE PROCEDURE AT A TERTIARY CARE HOSPITAL OF RAJASTHAN

Aim- To document the indications and analyze the histopathological spectrum of lesions in Whipple's specimen (Pancreaticoduodenectomy). Method- A total of 76 specimens of Whipple's procedure over a duration of 22 months (Jan 2021—Oct 2022) were received in our department and were subjected to detailed gross examination. Histopathological reporting of the specimens was done according to the CAP protocol. Out Resultsof 76 cases of Pancreaticoduodenectomy, malignancy was observed in 73 cases with 45 cases (59%) of Ampullary and Periampullary Adenocarcinoma, 12 cases (16%) of Pancreatic Adenocarcinoma, 6 cases (8%) of Cholangiocarcinoma, 6 cases (8%) of Duodenal Adenocarcinoma, 2 cases (2.5%) of Neuroendocrine tumor of Head of Pancreas and 2 cases (2.5%) of Neuroendocrine tumor of duodenum. 1 case (1.3%) each of chronic pancreatitis, autoimmune pancreatitis, and adenomatous proliferation of terminal bile duct were also reported. The neoplastic lesions were observed to have male preponderance and a mean age of 55.9 years. - Detaile Conclusion d and thorough gross examination of the Whipple's specimen is of utmost importance. Moderately dif ferentiated Adenocarcinoma was the most common histologic variant. Subtyping the tumor, reporting margin clearance, and lymphovascular and perineural invasion have great prognostic implications. Under rare conditions, Whipple's procedure may be done for non-neoplastic conditions as well.