Diethyl butylmalonate attenuates cognitive deficits and depression in 5×FAD mice
This study provides evidence that DBM ameliorates cognitive deficits and depression via improvement of the impairment of synaptic ultrastructure and neuroinflammation, suggesting that DBM is a potential drug candidate for treating AD-related neurodegeneration.
Authors
- Linlin Fu
- Wenbo Xu (ORCID: https://orcid.org/0009-0000-0385-0607)
- Qing Lin (ORCID: https://orcid.org/0000-0001-9598-9111)
- Xiaohui Ding (ORCID: https://orcid.org/0000-0002-9904-5369)
- Shuni Liu
- Ge Song (ORCID: https://orcid.org/0000-0002-3109-6477)
- Wei Pan (ORCID: https://orcid.org/0000-0001-5345-3829)
- Yuan Lai
- Fenfen Sun
- Yong-Sheng Zhang (ORCID: https://orcid.org/0000-0003-4162-0479)
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2024-11-11
- DOI
- https://doi.org/10.3389/fnins.2024.1480000
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.31
Funders
- Natural Science Foundation of Jiangsu Province