Causal impact of gut microbiota on five liver diseases: insights from mendelian randomization and single-cell RNA sequencing
Our MR results show a causal relationship between the GM and liver disease. Prevotella displays a notable protective effect. This finding may enhance the precision of GM-based therapies and offer new insights for clinical research.
Authors
- Jiali Deng (ORCID: https://orcid.org/0000-0001-9076-858X)
- Xiaoyu Hu (ORCID: https://orcid.org/0000-0002-8832-9446)
- Junli Zhang (ORCID: https://orcid.org/0009-0008-2491-4268)
- Fei Yu (ORCID: https://orcid.org/0000-0003-2622-6588)
- Yuxin Cheng (ORCID: https://orcid.org/0000-0001-9882-8153)
- Shuai Xiong
- Liyuan Hao (ORCID: https://orcid.org/0000-0001-9429-5134)
- Shenghao Li (ORCID: https://orcid.org/0000-0002-3196-7981)
- Na Li (ORCID: https://orcid.org/0000-0002-4761-5921)
- Xuanyi Chen (ORCID: https://orcid.org/0000-0002-8822-5903)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Province Hospital (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2024-11-11
- DOI
- https://doi.org/10.3389/fgene.2024.1362139
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- National Natural Science Foundation of China
- Sichuan Provincial Administration of Traditional Chinese Medicine
- National Human Genome Research Institute