Shared genetic architecture of psychiatric disorders and hemorrhoidal disease: a large-scale genome-wide cross-trait analysis
This study revealed a genetic correlation between four psychiatric disorders and HEM, identified pleiotropic loci, found multiple candidate genes, and confirmed causal relationships. This has enhanced our comprehension of the common genetic mechanisms of psychiatric disorders and HEM.
Authors
- Bowen Hu (ORCID: https://orcid.org/0000-0001-9815-8938)
- Zhangsendi Chen
- Zhe Chen (ORCID: https://orcid.org/0000-0002-9721-5301)
- Hongbo He (ORCID: https://orcid.org/0000-0002-7773-8834)
- Yuhong Jiang (ORCID: https://orcid.org/0000-0002-7324-700X)
- Weiguo Wang
- Ji Guo Sun
- Chunmei Yang
Institutions
- Central South University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2024-11-11
- DOI
- https://doi.org/10.3389/fpsyt.2024.1456182
- Primary Topic
- Anorectal Disease Treatments and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
- National Key Research and Development Program of China