pSTAT3 Expression is Increased in Advanced Prostate Cancer in Post‐Initiation of Androgen Deprivation Therapy
This study presents novel insights into the impact of ADT on the expression levels of pSTAT3<sup>Tyr705</sup> and pSTAT3<sup>Ser727</sup> in PCa. Cytoplasmic pSTAT3<sup>Ser727</sup> status of cancer-associated stromal cells in post-ADT samples may serve as an independent prognostic marker for OS and 5-year MFS, identifying prostate cancer patients prone to developing resistance to ADT.
Authors
- Bruce J. Trock (ORCID: https://orcid.org/0000-0003-3529-9295)
- Dominique Trudel (ORCID: https://orcid.org/0000-0001-9820-1772)
- Rebecka Hellsten (ORCID: https://orcid.org/0000-0002-3735-5636)
- Anders Bjartell (ORCID: https://orcid.org/0000-0002-5761-3786)
- Agnieszka Krzyzanowska (ORCID: https://orcid.org/0000-0002-1288-7054)
- Margareta Persson (ORCID: https://orcid.org/0000-0002-5300-0990)
- Tuomas Mirtti (ORCID: https://orcid.org/0000-0003-0455-9891)
- Piotr Białas (ORCID: https://orcid.org/0000-0001-9133-4177)
- Tamae Kobayashi
- Pekka Taimen (ORCID: https://orcid.org/0000-0001-8849-4604)
- Fred Saad (ORCID: https://orcid.org/0000-0003-2986-5617)
- Beatrice S. Knudsen (ORCID: https://orcid.org/0000-0002-7589-7591)
- Angelo M. De Marzo (ORCID: https://orcid.org/0000-0003-4847-5307)
- Isla P. Garraway (ORCID: https://orcid.org/0000-0002-1129-4636)
- Felicia Marginean
Institutions
- Poznan University of Medical Sciences (PL)
- University of Helsinki (FI)
- Johns Hopkins University (US)
- University of Turku (FI)
- University of California, Los Angeles (US)
- Lund University (SE)
- University of Utah (US)
- Johns Hopkins Medicine (US)
- Helsinki University Hospital (FI)
- Turku University Hospital (FI)
- Skåne University Hospital (SE)
- Centre Hospitalier de l’Université de Montréal (CA)
- VA Greater Los Angeles Healthcare System (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Hospital District of Helsinki and Uusimaa (FI)
- Université de Montréal (CA)
Publication Details
- Journal
- The Prostate
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1002/pros.24820
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- U.S. Department of Defense
- Johns Hopkins University
- Movember Foundation
- Swedish Cancer Foundation
- Cancerfonden
- Lunds Universitet
- Vetenskapsrådet
- Kungliga Fysiografiska Sällskapet i Lund
- Skånes universitetssjukhus
- National Institutes of Health
- Sidney Kimmel Comprehensive Cancer Center
- Fonds de Recherche du Québec - Santé
- National Cancer Institute
- DOD Prostate Cancer Research Program