Gene Expression Modulation of Markers Involved in Bone Formation and Resorption by Bisphenol A, Bisphenol F, Bisphenol S, and Bisphenol AF
The inhibition of both RANKL and OPG by the BPs, with a higher %inhibition of RANKL than of OPG, appears to rule out BP-induced activation of osteoclastogenesis via RANKL/RANK/OPG. Nevertheless, the effect of the BPs on the expression by osteoblasts of TGF-β1, TGF-β receptors, and VEGF indicates that these compounds can be responsible for major molecular changes in this cell population, contributing to their adverse effects on bone tissue.
Authors
- Concepción Ruíz (ORCID: https://orcid.org/0000-0003-4332-6812)
- Enrique García‐Recio (ORCID: https://orcid.org/0000-0001-9850-1214)
- Elvira De Luna‐Bertos (ORCID: https://orcid.org/0000-0002-4381-5942)
- Francisco Javier Manzano‐Moreno (ORCID: https://orcid.org/0000-0002-3176-7613)
- Anabel González‐Acedo (ORCID: https://orcid.org/0000-0002-8132-305X)
Institutions
- Universidad de Granada (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
Publication Details
- Journal
- Genes
- Published
- 2024-11-11
- DOI
- https://doi.org/10.3390/genes15111453
- Citations
- 3
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Universidad de Granada
- Junta de Andalucía