Up-regulation of HIF-1α in refractory sudden sensorineural hearing loss
This study suggests that HIF-1α activation inhibits HDAC2 expression, causing glucocorticoid resistance in refractory SSNHL. HIF-1α might serve as a potential biomarker to predict prognosis of refractory SSNHL.
Authors
- Ziwen Gao (ORCID: https://orcid.org/0000-0002-9565-8838)
- Xiaorui Chen (ORCID: https://orcid.org/0000-0002-4492-0883)
- Min‐Xin Guan (ORCID: https://orcid.org/0000-0001-5067-6736)
- Jie Hou (ORCID: https://orcid.org/0000-0001-6201-2873)
- Wandong She (ORCID: https://orcid.org/0000-0003-1923-8687)
- Wei Ma (ORCID: https://orcid.org/0000-0001-7612-0074)
- Wenyan Zhu (ORCID: https://orcid.org/0000-0003-4083-052X)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Soochow University (CN)
- Huaian First People’s Hospital (CN)
- Zhangjiagang First People's Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Suzhou Municipal Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Acta Otorhinolaryngologica Italica
- Published
- 2024-10-01
- DOI
- https://doi.org/10.14639/0392-100x-n3017
- Citations
- 2
- Primary Topic
- Vestibular and auditory disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.49
Funders
- National Natural Science Foundation of China