Associations of Circulating Platelet Endothelial Cell Adhesion Molecule‐1 Levels With Progression of Cerebral Small‐Vessel Disease, Cognitive Decline, and Incident Dementia
In dementia-free subjects, lower circulating PECAM-1 levels are associated with greater cerebral small-vessel disease progression and cognitive decline, thus warranting future study as a potential therapeutic target.
Authors
- Caroline Robert (ORCID: https://orcid.org/0000-0002-0381-593X)
- Narayanaswamy Venketasubramanian (ORCID: https://orcid.org/0000-0003-3593-6362)
- Siew Pang Chan (ORCID: https://orcid.org/0000-0001-6239-6483)
- Christopher Chen (ORCID: https://orcid.org/0000-0002-1047-9225)
- Eugene S.J. Tan (ORCID: https://orcid.org/0000-0001-7273-6883)
- Joyce Ruifen Chong (ORCID: https://orcid.org/0000-0002-2869-0096)
- Saima Hilal (ORCID: https://orcid.org/0000-0001-5434-5635)
- Yuek Ling Chai (ORCID: https://orcid.org/0000-0001-6646-1553)
- Ming Ann Sim (ORCID: https://orcid.org/0000-0002-5699-3553)
- Eddie Chong (ORCID: https://orcid.org/0009-0006-5818-1635)
- Mitchell K.P. Lai (ORCID: https://orcid.org/0000-0001-7685-1424)
- Yuan Cai (ORCID: https://orcid.org/0000-0002-7551-2866)
- Boon Yeow Tan
Institutions
- National University of Singapore (SG)
- Chinese University of Hong Kong (HK)
- Raffles Institution (SG)
- National University Heart Centre Singapore (SG)
- National University Health System (SG)
- St Luke's Hospital (SG)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1161/jaha.124.035133
- Citations
- 8
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.98
Funders
- National University of Singapore
- National University Health System
- Medical Research Council
- National Medical Research Council