Undifferentiated Pleomorphic Sarcoma: A Case Report

Undifferentiated pleomorphic sarcoma (UPS) is an uncommon and aggressive soft tissue tumor primarily affecting older adults, often presenting as a rapidly enlarging, painless mass in the extremities or other deep-seated locations. This case involves a 55-year-old woman who experienced a rapidly progressive and painful swelling in her right thigh following trauma. Imaging studies identified a large, lobulated tumor in the adductor muscles, close to the femur and pubic ramus, with no bone involvement or evidence of distant metastasis. The patient underwent surgical excision, and histopathological analysis confirmed high-grade UPS, necessitating adjuvant radiotherapy due to narrow surgical margins. Follow-up evaluations, including MRI scans at six months and one year, revealed no signs of disease recurrence. The case underscores the critical role of early detection, multidisciplinary treatment planning, and rigorous postoperative monitoring to improve outcomes and reduce the risk of recurrence in patients with UPS.