Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance
Reporting in Nature Communications, Kjeldsen and colleagues describe a redox mechanism of insulin clearance based on separation of A- and B chains. Exploiting an ultra-long-acting analog protected from classical clearance pathways, the study highlights principles of protein stability in pharmacology.
Authors
- Michael A. Weiss (ORCID: https://orcid.org/0000-0003-1325-1610)
Institutions
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1038/s41467-024-54006-6
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- Eli Lilly and Company
- Case Western Reserve University
- Hebrew University of Jerusalem
- National Institutes of Health
- School of Medicine, Indiana University