Semaglutide Ameliorates Diabetic Neuropathic Pain by Inhibiting Neuroinflammation in the Spinal Cord
These results indicate SEMA's neuroprotective benefits against diabetic neuropathic pain, most likely by reducing inflammation and oxidative stress by inhibiting astrocyte and microglial activity. Our findings suggest that we can repurpose GLP-1 agonists as potent anti-hyperalgesic and anti-inflammatory drugs to treat neuropathic pain without serious side effects.
Authors
- Sing-Ong Lee
- Wei-Hsiu Huang
- Yaswanth Kuthati (ORCID: https://orcid.org/0000-0002-5018-3736)
- Chih‐Shung Wong
Institutions
- Yuanpei University (TW)
- Cathay General Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Cells
- Published
- 2024-11-08
- DOI
- https://doi.org/10.3390/cells13221857
- Citations
- 16
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.22
Funders
- Cathay General Hospital