Precisive Incorporation of Multiple Nitrogen Sources into Benzoxazoles via an Iodine-Mediated Electrochemical Four-Component Reaction
An iodine-mediated electrochemical four-component reaction was developed to construct aromatic C-N bonds by making use of a simple nitrogen source, such as NH<sub>4</sub><sup>+</sup> and formamide. By virtue of this reaction, a variety of benzoxazoles bearing different substituents can be selectively modulated by using different bases. This protocol features a broad substrate scope and good scalability, is transition metal-free and chemical oxidant-free, and exhibits controlled product distribution. Additionally, it also enables a versatile platform for various isotope-labeled (<sup>15</sup>N and CD<sub>3</sub>) benzoxazoles.
Authors
- Jiajia Yu (ORCID: https://orcid.org/0000-0002-2677-1933)
- Tong Li
- Zhiyong Wang (ORCID: https://orcid.org/0000-0002-3400-2851)
- Kai Li (ORCID: https://orcid.org/0000-0002-7007-8140)
- Qi Sun (ORCID: https://orcid.org/0000-0002-6198-7836)
Institutions
- University of Science and Technology of China (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1021/acs.orglett.4c03844
- Citations
- 4
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- National Natural Science Foundation of China