Metal-Free Decarboxylative Cyanomethylation of β-Aryl/Heteroaryl Substituted α,β-Unsaturated Carboxylic Acids to γ-Ketonitriles
A decarboxylative cyanomethylation of β-aryl/heteroaryl substituted α,β-unsaturated carboxylic acids has been accomplished via C(sp<sup>3</sup>)-H activation of alkyl nitriles to afford diverse γ-ketonitriles by making use of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and <i>tert</i>-butyl hydroperoxide (TBHP). The present report offers a metal-free approach and is featured with a broad substitution pattern and functional group compatibility.
Authors
- Shiv Chand
- Saurabh Kumar (ORCID: https://orcid.org/0000-0002-8621-5189)
- Krishna Nand Singh (ORCID: https://orcid.org/0000-0001-9147-5463)
- Anup Sharma (ORCID: https://orcid.org/0000-0003-2691-5738)
Institutions
- Banaras Hindu University (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1021/acs.orglett.4c03994
- Citations
- 6
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- Council of Scientific and Industrial Research, India
- Science and Engineering Research Board