Matrine regulates autophagy in ileal epithelial cells in a porcine circovirus type 2-infected murine model
Our findings demonstrate that Matrine may be a novel, potential antiviral agent against PCV2 by activating intestine cellular autophagy, which provides a new strategy for host-directed drug discovery.
Authors
- Kuohai Fan (ORCID: https://orcid.org/0000-0003-1333-7270)
- Hong Wang (ORCID: https://orcid.org/0000-0002-6192-3082)
- Hua Zhang (ORCID: https://orcid.org/0000-0003-2875-7243)
- Hongquan Li (ORCID: https://orcid.org/0000-0002-2030-5587)
- Na Sun (ORCID: https://orcid.org/0000-0002-5894-8246)
- Panpan Sun (ORCID: https://orcid.org/0000-0002-0681-6145)
- Xiaozhong Zheng (ORCID: https://orcid.org/0000-0002-9803-9688)
- Wei Yin (ORCID: https://orcid.org/0000-0002-8457-8306)
- Yaogui Sun
Institutions
- Shanxi Agricultural University (CN)
- Queen's Medical Centre (GB)
- Centre for Inflammation Research (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-11-11
- DOI
- https://doi.org/10.3389/fmicb.2024.1455049
- Citations
- 2
- Primary Topic
- Animal Virus Infections Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.68