Electron-Donor-Mediated Divergent Transformation of Br–R<sub>F</sub> via EDA Complex for the Synthesis of Fluorine-Containing Oxindoles and Amides
We have developed an unprecedented electron-donor-controlled divergent reaction between <i>N</i>-alkylsulfonylated acrylamides and Br-R<sub>F</sub>, facilitated by an electron donor-acceptor (EDA) complex, for the synthesis of fluorine-containing oxindoles and amides. Key to this divergent transformation is the EDA complex generation by altering electron donors. This approach has several advantages, such as broad substrate scope, being metal-catalyst- and photocatalyst-free, and having good functional group tolerance.
Authors
- Wenchao Yang (ORCID: https://orcid.org/0000-0001-7729-7365)
- Shupeng Zhang (ORCID: https://orcid.org/0000-0001-6478-1537)
- Mei-Ling Yang
- Jingyi Cao
- Jin-Xin Lan
- Yicheng Zhang
Institutions
- Huaibei Normal University (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1021/acs.orglett.4c03830
- Citations
- 44
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 9.15
Funders
- Government of Jiangsu Province
- Natural Science Research of Jiangsu Higher Education Institutions of China