Kidney Hyperfiltration and Mitochondrial Changes Are Associated With eGFR Decline in Young People With Type 1 Diabetes
Hyperfiltration during adolescence is significantly associated with greater reduction in eGFR and higher risk of rapid eGFR decline after ∼9 years, following transition into young adulthood in type 1 diabetes. Urinary mtDNA:nDNA measured during adolescence may be a novel predictor of early changes in kidney function.
Authors
- Timothy W. Jones (ORCID: https://orcid.org/0000-0002-7989-1998)
- Uyen Thi Phuong Pham (ORCID: https://orcid.org/0000-0003-2050-3265)
- Elizabeth A. Davis (ORCID: https://orcid.org/0000-0003-4244-5473)
- Josephine M. Forbes (ORCID: https://orcid.org/0000-0002-5595-8174)
- Janelle Nisbet (ORCID: https://orcid.org/0000-0003-0513-430X)
- Tracey Baskerville
- Alison Pryke
- Mitchell A. Sullivan (ORCID: https://orcid.org/0000-0001-9913-4030)
- Ross S. Francis (ORCID: https://orcid.org/0000-0002-3995-7040)
- Paul Benitez‐Aguirre (ORCID: https://orcid.org/0000-0002-7687-2898)
- Fergus Cameron (ORCID: https://orcid.org/0000-0002-1566-7436)
- Kim C. Donaghue (ORCID: https://orcid.org/0000-0002-4210-7872)
- Liza Phillips
- Rani Whiddett (ORCID: https://orcid.org/0000-0002-5459-5519)
- Jennifer Couper (ORCID: https://orcid.org/0000-0003-4448-8629)
- Maria E. Craig (ORCID: https://orcid.org/0000-0001-6004-576X)
- Amelia K. Fotheringham (ORCID: https://orcid.org/0000-0002-3213-8923)
- David W. Johnson (ORCID: https://orcid.org/0000-0001-8453-7849)
- Helen L. Barrett (ORCID: https://orcid.org/0000-0001-7141-2086)
- Alison Griffin (ORCID: https://orcid.org/0000-0002-2699-5072)
- Maria Loredana Marcovecchio (ORCID: https://orcid.org/0000-0002-4415-316X)
- Andrew Cotterill
- R. Neil Dalton
Institutions
- The University of Sydney (AU)
- Royal Children's Hospital (AU)
- St Thomas' Hospital (GB)
- The University of Queensland (AU)
- QIMR Berghofer Medical Research Institute (AU)
- University of Cambridge (GB)
- Royal Hospital for Women (AU)
- Princess Margaret Hospital for Children (AU)
- Mater Misericordiae Hospital (AU)
- Princess Alexandra Hospital (AU)
- Children's Hospital at Westmead (AU)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- UNSW Sydney (AU)
- Children’s Health Queensland Hospital and Health Service (AU)
- Mater Research (AU)
- Evelina London Children's Healthcare (GB)
- Princess Alexandra Hospital (GB)
- Perth Children's Hospital
- The University of Adelaide (AU)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1210/clinem/dgae787
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16