Serum Anti-Aminoacyl-Transfer Ribonucleic Acid Synthetase Antibody Levels Are Involved in Rheumatoid Arthritis Complicated with Interstitial Lung Disease

<b>Objectives:</b> A common complication in patients with rheumatoid arthritis (RA) is interstitial lung disease (ILD). Antibodies (Abs) to anti-aminoacyl-transfer ribonucleic acid synthetase (ARS) are linked to ILD in patients with idiopathic inflammatory myopathies (IIM). There have been limited studies of anti-ARS Abs in RA. In this study, we examined anti-ARS Abs in ILD in patients with RA. <b>Methods:</b> Anti-ARS Abs in serum from patients with RA were measured. <b>Results:</b> There were higher anti-ARS Ab levels in RA patients with ILD (mean ± SDM, 16.3 ± 32.3 vs. 7.4 ± 7.0 (Index), <i>p</i> = 5.58 × 10<sup>-12</sup>), usual interstitial pneumonia (14.4 ± 24.4 vs. 7.4 ± 7.0 [Index], <i>p</i> = 3.14 × 10<sup>-12</sup>), and nonspecific interstitial pneumonia (17.9 ± 37.7 vs. 7.4 ± 7.0 (Index), <i>p</i> = 5.07 × 10<sup>-5</sup>) compared with patients without chronic lung disease. The area under the curve (AUC) of the receiver operating characteristic curve for anti-ARS Ab was too low to allow for discrimination among RA patients with/without chronic lung disease (0.608, 95% confidence interval (CI) 0.560-0.655, <i>p</i> = 8.69 × 10<sup>-6</sup>). Multiple logistic regression analyses of age, smoking status, anti-ARS Abs, as well as Steinbrocker stage generated an ARS-index with a high AUC value (0.707, 95%CI 0.662-0.752, <i>p</i> = 2.20 × 10<sup>-19</sup>). <b>Conclusions:</b> Anti-ARS Abs are related to ILD pathogenesis in RA and may be a biomarker for ILD.

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Journal
Journal of Clinical Medicine
Published
2024-11-10
DOI
https://doi.org/10.3390/jcm13226761
Primary Topic
Viral Infections and Immunology Research
Type
article
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article

Serum Anti-Aminoacyl-Transfer Ribonucleic Acid Synthetase Antibody Levels Are Involved in Rheumatoid Arthritis Complicated with Interstitial Lung Disease

Shigeto Tohma, Takashi Higuchi, Akira Okamoto, Kota Shimada et al.
Journal of Clinical Medicine
Viral Infections and Immunology Research
article

Serum Anti-Aminoacyl-Transfer Ribonucleic Acid Synthetase Antibody Levels Are Involved in Rheumatoid Arthritis Complicated with Interstitial Lung Disease

Shigeto Tohma, Takashi Higuchi, Akira Okamoto, Kota Shimada, Norie Yoshikawa, Hiroshi Furukawa, Kiyoshi Migita, Naoshi Fukui, Akiko Komiya, Atsushi Hashimoto, Misuzu Fujimori, Toshihiro Matsui, Masao Katayama, Koichiro Saisho, Shomi Oka
article en

Abstract

<b>Objectives:</b> A common complication in patients with rheumatoid arthritis (RA) is interstitial lung disease (ILD). Antibodies (Abs) to anti-aminoacyl-transfer ribonucleic acid synthetase (ARS) are linked to ILD in patients with idiopathic inflammatory myopathies (IIM). There have been limited studies of anti-ARS Abs in RA. In this study, we examined anti-ARS Abs in ILD in patients with RA. <b>Methods:</b> Anti-ARS Abs in serum from patients with RA were measured. <b>Results:</b> There were higher anti-ARS Ab levels in RA patients with ILD (mean ± SDM, 16.3 ± 32.3 vs. 7.4 ± 7.0 (Index), <i>p</i> = 5.58 × 10<sup>-12</sup>), usual interstitial pneumonia (14.4 ± 24.4 vs. 7.4 ± 7.0 [Index], <i>p</i> = 3.14 × 10<sup>-12</sup>), and nonspecific interstitial pneumonia (17.9 ± 37.7 vs. 7.4 ± 7.0 (Index), <i>p</i> = 5.07 × 10<sup>-5</sup>) compared with patients without chronic lung disease. The area under the curve (AUC) of the receiver operating characteristic curve for anti-ARS Ab was too low to allow for discrimination among RA patients with/without chronic lung disease (0.608, 95% confidence interval (CI) 0.560-0.655, <i>p</i> = 8.69 × 10<sup>-6</sup>). Multiple logistic regression analyses of age, smoking status, anti-ARS Abs, as well as Steinbrocker stage generated an ARS-index with a high AUC value (0.707, 95%CI 0.662-0.752, <i>p</i> = 2.20 × 10<sup>-19</sup>). <b>Conclusions:</b> Anti-ARS Abs are related to ILD pathogenesis in RA and may be a biomarker for ILD.

Journal of Clinical MedicineVol. 13(22)
Fukushima Medical University (JP), Tokyo University of the Arts (JP), National Sagamihara Hospital (JP), Nagasaki Medical Center (JP), Imamura Hospital (JP), Himeji Medical Center (JP), National Institute of Technology, Miyakonojo College (JP), Tokyo Metropolitan Tama Medical Center (JP), Nagoya Medical Center (JP), Tokyo National Hospital (JP), The University of Tokyo (JP)
Bristol-Myers Squibb, Pfizer, Takeda Science Foundation, Japan Research Foundation for Clinical Pharmacology, Nakatomi Foundation, Mitsui Sumitomo Insurance Welfare Foundation, Abbott Japan, Japan Agency for Medical Research and Development, Eisai, Astellas Pharma, Daiwa Securities Health Foundation, Astellas Foundation for Research on Metabolic Disorders, Teijin Pharma, Mitsubishi Tanabe Pharma Corporation, Pfizer Japan, Chugai Pharmaceutical, Japan Society for the Promotion of Science
Good health and well-being
Openalex Percentile: Top 63%
Viral Infections and Immunology Research
DOIOpen Access PDFOpenAlex
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