Oxoammonium-Catalyzed Oxidation of <i>N</i> -Substituted Amines
We report the development of oxoammonium-catalyzed oxidation of <i>N</i>-substituted amines via a hydride transfer mechanism. Steric and electronic tuning of catalyst led to complementary sets of conditions that can oxidize a broad scope of carbamates, sulfonamides, ureas, and amides into the corresponding imides. The reaction was further demonstrated on a 100-g scale using a continuous flow setup.
Authors
- Frédéric G. Buono (ORCID: https://orcid.org/0000-0001-7585-0438)
- Bartosz Górski (ORCID: https://orcid.org/0000-0003-4644-9789)
- Zhen Lei (ORCID: https://orcid.org/0000-0002-6608-7933)
- Jonas Rein (ORCID: https://orcid.org/0000-0001-8237-6519)
- Song Lin (ORCID: https://orcid.org/0000-0002-8880-6476)
- Yukun Cheng (ORCID: https://orcid.org/0000-0002-2379-9404)
Institutions
- Cornell University (US)
- Boehringer Ingelheim (United States) (US)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1021/jacs.4c11758
- Citations
- 10
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.50
Funders
- Boehringer Ingelheim
- Camille and Henry Dreyfus Foundation
- National Institute of General Medical Sciences