MECHANISMS OF STRUCTURAL FEATURES IN THE CEREBRAL CORTEX IN MODELS OF PREMATURE AGING OF NERVOUS TISSUE AFTER BACTERIAL LIPOPOLYSACCHARIDE

Introduction. Many chemical compounds affect brain neurons differently than other cell populations. This is provided by the protective potential of the blood-brain barrier (BBB). One of the compounds capable of passing through the BBB is bacterial lipopolysaccharide (LPS). It can cause irreversible morphological changes in the neurons of the cerebral cortex. The aim of the work is to study the mechanisms of neuronal damage and death. Material and methods. More than 50 sources for 15 past years were analyzed at PubMed and Elibrary databases. Results. Astrocytes recognize LPS due to toll-like receptors, and glial macrophages are also able to capture areas of the external bacterial membrane with LPS. However, variations in the dose of LPS, the method and frequency of its administration have different effects on the morphology of the cerebral cortex. In particular, it is relevant to study changes similar to those in aging and neurodegenerative processes. Conclusion. The review examines the structural changes of neurons and glia in the use of LPS in adult animals. The authors conclude that repeated systemic administration of non-septic doses of LPS is most suitable for modeling aging-like changes, but it is necessary to develop a standardized model of such administration.