A substitution at the cytoplasmic tail of the spike protein enhances SARS-CoV-2 infectivity and immunogenicity
This study was supported by grants from the National Key Research and Development Plan of China (2021YFC2302405, 2022YFC2303200, 2021YFC2300200 and 2022YFC2303400), the National Natural Science Foundation of China (32188101, 32200772, 82422049, 82241082, 32270182, 82372254, 82271872, 82341046, 32100755 and 82102389), Shenzhen Medical Research Fund (B2404002, A2303036), the Shenzhen Bay Laboratory Startup Fund (21330111), Shenzhen San-Ming Project for Prevention and Research on Vector-borne Diseases (SZSM202211023), Yunnan Provincial Science and Technology Project at Southwest United Graduate School (202302AO370010). The New Cornerstone Science Foundation through the New Cornerstone Investigator Program, and the Xplorer Prize from Tencent Foundation.
Authors
- Penghua Wang (ORCID: https://orcid.org/0000-0002-7332-1871)
- Mingyao Tian
- Xinyu Zhuang
- Shumin Liao
- Yibin Zhu (ORCID: https://orcid.org/0000-0002-8088-3960)
- Yanhong Huang (ORCID: https://orcid.org/0000-0001-5027-1544)
- Xinyang Yu (ORCID: https://orcid.org/0000-0002-3341-0183)
- Wanbo Tai (ORCID: https://orcid.org/0000-0002-9864-8993)
- Yubin Liu (ORCID: https://orcid.org/0000-0002-5531-6972)
- Xingzhao Chen
- Guocan Yu (ORCID: https://orcid.org/0000-0003-1157-4184)
- Yuhan Li (ORCID: https://orcid.org/0000-0002-0133-7065)
- Yan Liu (ORCID: https://orcid.org/0000-0003-4242-4840)
- Gong Cheng (ORCID: https://orcid.org/0009-0004-3609-5336)
- Li Liang (ORCID: https://orcid.org/0000-0002-4108-5464)
- Jianying Liu (ORCID: https://orcid.org/0000-0002-2189-2533)
- Xianwen Zhang (ORCID: https://orcid.org/0000-0001-5329-7571)
- Huicheng Shi
- Rui Mei (ORCID: https://orcid.org/0009-0005-5684-5306)
Institutions
- Peking University (CN)
- Southern University of Science and Technology (CN)
- Changchun Institute of Applied Chemistry (CN)
- Shenzhen Bay Laboratory (CN)
- Center for Life Sciences (CN)
- UConn Health (US)
- Tsinghua University (CN)
Publication Details
- Journal
- EBioMedicine
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1016/j.ebiom.2024.105437
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- Tencent
- National Natural Science Foundation of China
- Shenzhen Bay Laboratory