EPID-37. PROGNOSIS OF BRAIN METASTASES PATIENTS WITH WHOLE BRAIN RADIATION THERAPY (WBRT) VS NON-WBRT AT THE NATIONAL CANCER CENTER OF INDONESIA, DHARMAIS HOSPITAL

Abstract BACKGROUND Limited treatment options for brain metastases (BM) remain a challenge for many cancer centers in Indonesia. To improve overall survival, Whole Brain Radiation Therapy (WBRT) is still widely used in many Indonesian cancer centers This study aims to evaluate the effectiveness of WBRT vs non-WBRT for overall survival of brain metastases patients. METHOD This retrospective study observed 148 brain metastasis patients admitted to our hospital from January 1st, 2021 to December 31st, 2022 and we followed their overall survival up to July 1st, 2023. The brain metastasis is confirmed by brain MRI. In addition to overall survival, we collected information on age, sex, primary tumor types, sides of metastasis, and treatment received (WBRT, non-WBRT, and surgery). To examine the overall survival among treatment received and tumor characteristics, we present median survival time, Kaplan-Meier curves, and its log-rank statistics using Stata program version 17. Additionally, we use Cox regression for further analysis. RESULTS The overall median survival of these patients was 4.3 months. Patients receiving WBRT exhibit higher survival rates than non-WBRT as presented in their median survival rates (1.5 months vs 6.9 months). The primary tumors (breast, lung, and others) have no difference in the median survival rates. The survival rate trends using Kaplan-Meier showed a significant difference between patients with WBRT vs non-WBRT (log-rank p=0.0). A Cox regression shows hazard rates(HR) for patients receiving WBRT =0.40 and it shows only a small change when adjusted for surgery and other variables. CONCLUSIONS Brain metastasis patients who received WBRT have better survival than non-WBRT patients who could reduce HR to 0.4. This means that WBRT patients are protected 60% of the risk for overall survival.