Neurodevelopmental Outcomes after Multiple General Anesthetic Exposures before 5 Years of Age: A Cohort Study
Multiple GA exposure before 5 years of age was associated with reduced performance in general intelligence score and some domains of neurodevelopmental assessments. The clinical significance of our results must be cautiously interpreted in light of several sources of limitations including small sample size and unadjusted residual confounding. This study illustrates the limitations of trial data sets that may not be fit for the purpose for the secondary analysis.
Authors
- Nicola Disma (ORCID: https://orcid.org/0000-0002-2960-9333)
- Andrew Davidson (ORCID: https://orcid.org/0000-0002-7050-7419)
- Jurgen C. de Graaff (ORCID: https://orcid.org/0000-0002-2168-7900)
- Anneke Grobler (ORCID: https://orcid.org/0000-0002-7809-7688)
- Mary Ellen McCann (ORCID: https://orcid.org/0000-0002-5173-6582)
- Graham Bell (ORCID: https://orcid.org/0000-0003-1149-0888)
- Annie Xin (ORCID: https://orcid.org/0000-0003-4964-5865)
- Liam Dorris (ORCID: https://orcid.org/0000-0002-9502-3154)
- Davinia E. Withington (ORCID: https://orcid.org/0000-0002-3735-0552)
Institutions
- Boston Children's Hospital (US)
- Royal Children's Hospital (AU)
- The University of Melbourne (AU)
- Cornell University (US)
- Montreal Children's Hospital (CA)
- Royal Hospital for Children (GB)
- Istituto Giannina Gaslini (IT)
- Murdoch Children's Research Institute (AU)
- Weill Cornell Medicine (US)
- McGill University (CA)
Publication Details
- Journal
- Anesthesiology
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1097/aln.0000000000005293
- Citations
- 21
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 8.63
Funders
- Canadian Institutes of Health Research