Electrochemical Synthesis of Quinazolines: N–H/C(sp<sup>3</sup>)–H Coupling of <i>o</i>-Carbonyl Anilines with Amino Acids and Amines
A mild and efficient electrochemical protocol for the synthesis of quinazolines through N-H/C(sp<sup>3</sup>)-H coupling of <i>o</i>-carbonyl anilines with natural amino acids/amines has been developed. The products quinazolines can easily be isolated in moderate to excellent yields under external chemical oxidant-free conditions. Moreover, this reaction can be safely conducted on gram scale.
Authors
- Zirong Li
- Xiaolan Xu (ORCID: https://orcid.org/0000-0001-8476-3643)
- Jie Zhou (ORCID: https://orcid.org/0000-0003-3389-7515)
- Longqiang Ye
- Hua‐Jian Xu (ORCID: https://orcid.org/0000-0002-0789-3484)
- Jiwei Wu (ORCID: https://orcid.org/0000-0002-7147-6116)
- Di Zhang (ORCID: https://orcid.org/0000-0001-7190-1621)
- Kaixuan Li
- Lingxiang Yu
Institutions
- Hefei University of Technology (CN)
- Anhui University of Science and Technology (CN)
- Anhui Medical University (CN)
- Anhui Science and Technology University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1021/acs.joc.4c01173
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China
- Anhui University of Science and Technology
- Natural Science Foundation of Anhui Province
- Fundamental Research Funds for the Central Universities