Mechanism of vitamin C alleviating the immunotoxicity of 17α-methyltestosterone in Carassius auratus
In summary, 25-50 mg/kg VC alleviated inhibitory effect of MT on immune-related genes in C. auratus liver, reducing MT-induced tissue damage. VC not only alleviated inflammation, oxidative stress, and immunotoxicity induced by MT through the regulation of the mTOR, MAPK, and Wnt signaling pathways, but also indirectly enhanced cellular antioxidant defense mechanisms by regulating the NRF2 pathway. This provides a theoretical basis for VC application in aquaculture, improving fish health and increasing efficiency.
Authors
- Yu Liu (ORCID: https://orcid.org/0000-0002-9702-349X)
- Qing Liu (ORCID: https://orcid.org/0000-0002-6163-2488)
- Zijun Xiong (ORCID: https://orcid.org/0000-0003-3923-0703)
- Xian-Zong Wang (ORCID: https://orcid.org/0000-0002-4046-0330)
- Jing Song (ORCID: https://orcid.org/0000-0003-3319-9063)
- Tongyao Li
- Weiya Rong
- Weiwei Wang (ORCID: https://orcid.org/0000-0003-3995-2095)
- Lu Cao (ORCID: https://orcid.org/0000-0002-1847-068X)
- Haiyan Zhao
- Gen Chen (ORCID: https://orcid.org/0000-0001-5468-3773)
- Yue Chen (ORCID: https://orcid.org/0000-0002-6555-2901)
- Shaozhen Liu (ORCID: https://orcid.org/0000-0002-1027-7009)
- Yan Liu (ORCID: https://orcid.org/0009-0003-3120-3011)
Institutions
- Shanxi Agricultural University (CN)
- Yantai University (CN)
- Jinzhong University (CN)
- People's Hospital of Yangzhong (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1186/s12864-024-10967-y
- Citations
- 4
- Primary Topic
- Environmental Toxicology and Ecotoxicology
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shanxi Province
- Natural Science Foundation of Shandong Province