Design, creation, and use of the Test Us Bank (TUB) COVID-19 sample biorepository

Shortly after the first case of SARS-CoV-2 was diagnosed a public health emergency (PHE) was declared and a multi-agency response was initiated within the US federal government to create and propagate testing capacity. As part of this response, an unprecedented program designated Rapid Acceleration of Diagnostics (RADx) Tech was established by the National Institutes of Health (NIH) to facilitate the development of point-of-care tests for the COVID-19. The RADx Tech Clinical Studies Core (CSC), located at the University of Massachusetts Chan Medical School (UMass Chan), with partnering academic, private, and non-governmental organizations around the country, was tasked with developing clinical studies to support this work. This manuscript details development of a biorepository specifically focused on the collection and storage of samples designed for diagnostic platform development. It highlights the unified collection and annotation process that enabled gathering a diverse set of samples. This diversity encompasses the geography and backgrounds of the participants as well as sample characteristics such as variant type and RT-PCR cycle threshold (CT) value of the corresponding reference sample on a uniform clinical reference platform.

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Publication Details

Journal
BMC Infectious Diseases
Published
2024-11-11
DOI
https://doi.org/10.1186/s12879-024-10154-0
Citations
1
Primary Topic
SARS-CoV-2 detection and testing
Type
article
Field-Weighted Citation Impact
0.39

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Design, creation, and use of the Test Us Bank (TUB) COVID-19 sample biorepository

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BMC Infectious Diseases
SARS-CoV-2 detection and testing
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Design, creation, and use of the Test Us Bank (TUB) COVID-19 sample biorepository

Nancy Elder, Denis B. Buxton, Julia Ferranto, John Broach, Karl Simin, Bernadette Shaw, Barcey T. Levy, Simisola O. Oludare, Laurel O’Connor, Nisha Fahey, Paul Hartin, Seanan Tarrant, William Heetderks, Jeanette M. Daly, Bryan Buchholz, Janvi Nanavati, Yukari Carol Manabe, Robert L. Murphy, Kim Parang, Timothy F. Kowalik, Zaida Palmer, Colton Wright, David D. McManus, Laura K. Ferrara, Megan Schmidt, Matthew Caputo, Taylor Orwig, Doyle V. Ward, S. Behar, Julie Flahive, Carly Herbert, Grant Theron, Laura Gibson, Ainat Koren, Apurv Soni, Nathaniel Hafer, Felix Sogade, Kelsey Woods, Heidi Collins Fantasia, Jennifer Bacani McKenney, Bruce Barton, Chad J. Achenbach, Benedict Kalibala, Dana Ritland, Agha W Mirza, Christi Baron, Cedrice Davis, Allen Grenier, E. Brent, LeAnn Michaels, L. Marchand
article en
1 citations

Abstract

Shortly after the first case of SARS-CoV-2 was diagnosed a public health emergency (PHE) was declared and a multi-agency response was initiated within the US federal government to create and propagate testing capacity. As part of this response, an unprecedented program designated Rapid Acceleration of Diagnostics (RADx) Tech was established by the National Institutes of Health (NIH) to facilitate the development of point-of-care tests for the COVID-19. The RADx Tech Clinical Studies Core (CSC), located at the University of Massachusetts Chan Medical School (UMass Chan), with partnering academic, private, and non-governmental organizations around the country, was tasked with developing clinical studies to support this work. This manuscript details development of a biorepository specifically focused on the collection and storage of samples designed for diagnostic platform development. It highlights the unified collection and annotation process that enabled gathering a diverse set of samples. This diversity encompasses the geography and backgrounds of the participants as well as sample characteristics such as variant type and RT-PCR cycle threshold (CT) value of the corresponding reference sample on a uniform clinical reference platform.

BMC Infectious DiseasesVol. 24(1)
South African Medical Research Council (ZA), Northwestern University (US), University of Iowa (US), National Institutes of Health (US), University of Massachusetts Lowell (US), Johns Hopkins University (US), Oregon Health & Science University (US), University of Massachusetts Chan Medical School (US), Stellenbosch University (ZA), Johns Hopkins Medicine (US), Georgia Arrhythmia Consultants (US), National Heart, Lung, and Blood Institute (US), University of Kansas Medical Center (US), Research Network (United States) (US), SUNY Fredonia (US)
Johns Hopkins University, South African Medical Research Council, Universiteit Stellenbosch, National Institutes of Health, Medical Research Council
Partnerships for the goals
Openalex Percentile: Top 35%
SARS-CoV-2 detection and testing
0.39
DOIOpen Access PDFOpenAlex
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