Transient Receptor Potential Melastatin 8 Contributes to Cystitis‐Induced Neuronal Sprouting and Pain Hypersensitivity Through <scp>AKT</scp>/<scp>mTOR</scp> Signaling Pathway in Interstitial Cystitis/Bladder Pain Syndrome
TRPM8 can induce pain hypersensitivity and sensory nerve proliferation by activating Akt/mTOR pathway and raising the expression of IL-6 and norepinephrine in IC/BPS models. These findings offer new perspectives on IC/BPS treatment.
Authors
- Ran Chang (ORCID: https://orcid.org/0000-0002-9311-2268)
- Peng Zhang (ORCID: https://orcid.org/0000-0001-9004-8144)
- Liyang Wu (ORCID: https://orcid.org/0000-0002-3404-7232)
Institutions
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- China Rehabilitation Research Center (CN)
Publication Details
- Journal
- LUTS Lower Urinary Tract Symptoms
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1111/luts.12537
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00