Monocyte/macrophage pyroptosis and C5b-9-induced cyst enlargement in Pkd1−/− mice
C5b-9 infusion promoted renal tubular epithelial cell proliferation by inducing pyroptosis of Ly6C+ monocytes/macrophages, contributing to progressive cyst enlargement in chronic-onset PKD mice.
Authors
- Changlin Mei
- Minghui Song
- Meihan Chen
- Cheng Xue (ORCID: https://orcid.org/0000-0002-4132-9406)
- Zhiguo Mao (ORCID: https://orcid.org/0000-0003-2759-1421)
- Deyang Kong (ORCID: https://orcid.org/0000-0002-5044-2531)
- Jiayi Lv
- Yang Yang (ORCID: https://orcid.org/0000-0003-4347-0064)
- Ma Lu (ORCID: https://orcid.org/0000-0001-8736-279X)
- Shuwei Song (ORCID: https://orcid.org/0009-0008-7422-6041)
- Jie Zhou (ORCID: https://orcid.org/0000-0003-2818-6620)
Institutions
- Second Military Medical University (CN)
- 307th Hospital of Chinese People’s Liberation Army (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- People's Liberation Army 401 Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- Hainan 301 Hospital (CN)
- Shenzhen Bao'an District People's Hospital (CN)
- The 309th Hospital of Chinese People's Liberation Army (CN)
- Shuguang Hospital (CN)
- Chinese People's Liberation Army (CN)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1093/ndt/gfae262
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Natural Science Foundation of China