Common Patterns and Unique Threats in Antimicrobial Resistance as Demonstrated by Global Gonococcal Surveillance
The rapid emergence of antimicrobial-resistant strains of Neisseria gonorrhoeae threatens treatment options and control efforts. The Uniformed Services University Gonococcal Reference Laboratory and Repository of the Global Emerging Infections Surveillance Program receives isolates from several geographically distinct regions worldwide. We analyzed 962 isolates collected during 2014-2022 for genomic and phenotypic antimicrobial resistance. Resistance to antimicrobial drugs previously used for gonococcal infections was high, but of most concern were increases of resistance to currently used antibiotic drugs, such as extended-spectrum cephalosporins and the alternative antibiotic treatment gentamicin. The percentage of isolates with reduced susceptibility to ceftriaxone was 3.6%, to cefixime was 2.5%, and to gentamicin was 15.0%. Although isolates were collected from populations of limited diversity, 706 (73.4%) of isolates demonstrated novel multiantigen sequence types, and 225 (23.4%) had novel multilocus sequence types. Continued surveillance of N. gonorrhoeae is essential to monitoring the prevalence and spread of resistant organisms worldwide.
Authors
- Ann E. Jerse (ORCID: https://orcid.org/0000-0002-5118-3172)
- Reuel Sandy
- Nelson Dozier
- Maneerat Somsri
- Woradee Lurchachaiwong (ORCID: https://orcid.org/0000-0002-5402-1849)
- Nonlawat Boonyalai (ORCID: https://orcid.org/0000-0002-9058-0840)
- Denis K. Byarugaba (ORCID: https://orcid.org/0000-0002-4175-5659)
- Melissa J. Martin (ORCID: https://orcid.org/0000-0002-8772-9392)
- Supriya D. Mehta (ORCID: https://orcid.org/0000-0002-7926-2489)
- Eric C. Garges (ORCID: https://orcid.org/0000-0002-1238-7228)
- Hunter Jackson Smith (ORCID: https://orcid.org/0000-0002-3591-588X)
- Paul Ríos (ORCID: https://orcid.org/0000-0002-5690-3378)
- Nithinart Chaitaveep
- Katie Bartlett (ORCID: https://orcid.org/0009-0007-3117-5048)
- Naiki Attram (ORCID: https://orcid.org/0000-0003-0286-1990)
- Somchai Sriplienchan
- Bernard Erima
- Hannah Kibuuka (ORCID: https://orcid.org/0000-0002-2293-1944)
- Umaporn Suksawad
- Adriana Le Van (ORCID: https://orcid.org/0000-0002-8209-9520)
- Walter Agingu
- Nazia Rahman
- Anna Nanava
- Wilawan Oransathit
- Dutsadee Peerapongpaisarn
- Fred Wabwire‐Mangen
- Tamar Akhvlediani
- Hope O. Kabatasi
- Wirote Oransathit
- Krit Harncharoenkul
Publication Details
- Journal
- Emerging infectious diseases
- Published
- 2024-10-01
- DOI
- https://doi.org/10.3201/eid3014.240296
- Citations
- 8
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 2.76
Funders
- Uniformed Services University of the Health Sciences