Open-label, controlled, phase 2 clinical trial assessing the safety, efficacy, and pharmacokinetics of INM004 in pediatric patients with Shiga toxin-producing Escherichia coli–associated hemolytic uremic syndrome
INM004 showed an adequate safety profile. Efficacy non-statistically significant trends suggesting a beneficial effect in the amelioration of kidney injury were observed. These results encourage the conduction of a phase 3 study of INM004 in pediatric patients with STEC-HUS.
Authors
- Ian Roubicek
- Iliana Principi
- Laura Alconcher (ORCID: https://orcid.org/0000-0002-2130-0307)
- Vanesa Zylberman (ORCID: https://orcid.org/0000-0002-8092-4558)
- Oscar Amoreo
- Alejandro Balestracci (ORCID: https://orcid.org/0000-0003-4083-2066)
- María Laura Flores Tonfi
- Marta Rivas
- Flavia Ramírez (ORCID: https://orcid.org/0000-0002-8833-507X)
- Ana Paula Spizzirri (ORCID: https://orcid.org/0000-0002-4440-9567)
- Claudia Seminara
- Lidia Ghezzi
- Linus Spatz
- Santiago Sanguineti
- Jorge Montero
- Mariana Pichel
- Pablo Bonany (ORCID: https://orcid.org/0000-0002-5531-6964)
- Ángela Suárez (ORCID: https://orcid.org/0000-0003-1810-7351)
- Luis Flynn
- Mariana Colonna
- Carolina Massa
- María Carolina Bettendorff
- Paula Coccia (ORCID: https://orcid.org/0000-0001-8615-6847)
- Marina P. Valerio (ORCID: https://orcid.org/0000-0002-4846-618X)
- Fernando A. Goldbaum (ORCID: https://orcid.org/0000-0001-6235-3002)
- Alicia Fayad
- María Valeria Blumetti
- Marta Adragna
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Garrahan Hospital (AR)
- Hospital Italiano de Buenos Aires (AR)
- Hospital Pedro de Elizalde (AR)
- Centro Científico Tecnólogico - Rosario (AR)
- Infant Foundation (AR)
- Helios Salud (AR)
- Asociación por los Derechos Civiles (AR)
- Hospital de Niños Superiora Sor María Ludovica (AR)
- Hospital de Niños de la Santísima Trinidad (AR)
- Hospital El Cruce (AR)
- Instituto de Neurología de Buenos Aires (AR)
- Hospital General de Niños Ricardo Gutierrez (AR)
- Fundacion Allende (AR)
- Universidad Nacional del Comahue (AR)
Publication Details
- Journal
- Pediatric Nephrology
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1007/s00467-024-06583-3
- Citations
- 10
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.40