More powerful dysregulation of Helicobacter pylori East Asian-type CagA on intracellular signalings
The study provides transcriptome evidence of CagA-associated intracellular regulation during H. pylori infection, demonstrating that CagA<sup>E</sup> exerts stronger effects on intracellular signaling than CagA<sup>W</sup>. These findings offer insights into the heightened carcinogenic potential of CagA<sup>E</sup> in H. pylori-induced gastric cancer.
Authors
- Xiaofei Ji (ORCID: https://orcid.org/0000-0002-0461-1007)
- Huilin Zhao (ORCID: https://orcid.org/0009-0006-4449-354X)
- Shuzhen Liu (ORCID: https://orcid.org/0000-0003-4502-7816)
- Jiankai Feng (ORCID: https://orcid.org/0000-0002-7621-6356)
- Boqing Li (ORCID: https://orcid.org/0000-0001-8593-3499)
- Hao Wu (ORCID: https://orcid.org/0000-0001-9222-2521)
- Bin Wang (ORCID: https://orcid.org/0000-0001-7862-6853)
- Ying Zhang
- Feifan Wang (ORCID: https://orcid.org/0000-0002-8204-8758)
- Jianhui Zhang (ORCID: https://orcid.org/0000-0002-6362-4027)
- Xinying Cao
- Zekun Sun
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1186/s12866-024-03619-4
- Citations
- 8
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 4.58
Funders
- Natural Science Foundation of Shandong Province
- Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China