Association of Initial Side of Brain Atrophy With Clinical Features and Disease Progression in Patients With <i>GRN</i> Frontotemporal Dementia
FTD-<i>GRN</i> affects the brain hemispheres asymmetrically and causes 2 anatomical asymmetry patterns depending on the side of the disease onset. We demonstrated that these 2 anatomical asymmetry patterns present different symptoms, severity at the time of the first visit, and different disease courses. Our results also suggest brain asymmetry as a possible biomarker of conversion in <i>GRN</i> carriers.
Authors
- John Cornelis Van Swieten (ORCID: https://orcid.org/0000-0001-6278-6844)
- Sandro Sorbi (ORCID: https://orcid.org/0000-0002-0380-6670)
- Caroline Graff (ORCID: https://orcid.org/0000-0002-9949-2951)
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- Agnès Pérez‐Millan (ORCID: https://orcid.org/0000-0002-3006-9792)
- James Benedict Rowe (ORCID: https://orcid.org/0000-0001-7216-8679)
- Albert Lladó (ORCID: https://orcid.org/0000-0002-5066-4150)
- Alexander Gerhard (ORCID: https://orcid.org/0000-0002-8071-6062)
- Christopher Robert Butler (ORCID: https://orcid.org/0000-0002-7502-9284)
- Matthis Synofzik (ORCID: https://orcid.org/0000-0002-2280-7273)
- Marijne Vandebergh (ORCID: https://orcid.org/0000-0001-9645-2615)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Alexandre de Mendonça (ORCID: https://orcid.org/0000-0002-0488-1453)
- Jordi Juncà‐Parella (ORCID: https://orcid.org/0000-0002-4772-2647)
- Eve Ferry‐Bolder (ORCID: https://orcid.org/0009-0006-5083-0901)
- Mircea Balasa (ORCID: https://orcid.org/0000-0002-1795-4228)
- Isabelle Le Ber (ORCID: https://orcid.org/0000-0002-2508-5181)
- Raquel Sánchez‐Valle (ORCID: https://orcid.org/0000-0001-7750-896X)
- Rosa Rademakers (ORCID: https://orcid.org/0000-0002-4049-0863)
- Harro Seelaar (ORCID: https://orcid.org/0000-0003-1989-7527)
- Sergi Borrego‐Écija (ORCID: https://orcid.org/0000-0003-2557-0010)
- Pietro Tiraboschi (ORCID: https://orcid.org/0000-0002-2171-1720)
- Phoebe H. Foster (ORCID: https://orcid.org/0000-0001-6300-6598)
- Florence Pasquier (ORCID: https://orcid.org/0000-0001-9880-9788)
- Arabella Bouzigues (ORCID: https://orcid.org/0000-0002-0267-8590)
- Isabel Santana (ORCID: https://orcid.org/0000-0002-8114-9434)
- Lize Corrine Jiskoot (ORCID: https://orcid.org/0000-0002-1120-1858)
- Lucy Louise Russell (ORCID: https://orcid.org/0000-0001-5023-5893)
- Jonathan D. Rohrer (ORCID: https://orcid.org/0000-0002-6155-8417)
- Markus Otto (ORCID: https://orcid.org/0000-0003-4273-4267)
- Rik R. Vandenberghe (ORCID: https://orcid.org/0000-0001-6237-2502)
- Elizabeth C. Finger (ORCID: https://orcid.org/0000-0003-4461-7427)
- Daniela Galimberti (ORCID: https://orcid.org/0000-0002-9284-5953)
- Mario Masellis (ORCID: https://orcid.org/0000-0002-6244-2096)
- Fermín Moreno (ORCID: https://orcid.org/0000-0001-5200-3164)
- Robert Laforce (ORCID: https://orcid.org/0000-0002-2031-490X)
- Barbara Borroni (ORCID: https://orcid.org/0000-0001-9340-9814)
- Simon Ducharme (ORCID: https://orcid.org/0000-0002-7309-1113)
Institutions
- Fundació Clínic per a la Recerca Biomèdica (ES)
Publication Details
- Journal
- Neurology
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1212/wnl.0000000000209944
- Citations
- 10
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 3.69
Funders
- Fundación BBVA
- Wellcome Trust
- Weston Brain Institute
- EU Joint Programme – Neurodegenerative Disease Research
- Alzheimer's Society
- National Institute for Health and Care Research
- Brain Research Trust
- University College London
- ZonMw
- Ministero della Salute
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Stockholms Läns Landsting
- Stichting Dioraphte
- Alzheimer Nederland
- UK Dementia Research Institute
- Canadian Institutes of Health Research
- Medical Research Council
- Instituto de Salud Carlos III
- NIHR Cambridge Biomedical Research Centre