Association of Changes in Cerebral and Hypothalamic Structure With Sleep Dysfunction in Patients With Genetic Frontotemporal Dementia
These findings suggest that sleep dysfunction in patients with genetic FTD may be attributable to atrophy in sleep-relevant hypothalamic subunits, with the most severe and consistent deficits observed in MAPT carriers. While biologically plausible, our statistical approach cannot confirm a causal link between atrophy and sleep disturbances.
Authors
- John Cornelis Van Swieten (ORCID: https://orcid.org/0000-0001-6278-6844)
- Sandro Sorbi (ORCID: https://orcid.org/0000-0002-0380-6670)
- Caroline Graff (ORCID: https://orcid.org/0000-0002-9949-2951)
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- M. Mallar Chakravarty (ORCID: https://orcid.org/0000-0002-0759-5508)
- James Benedict Rowe (ORCID: https://orcid.org/0000-0001-7216-8679)
- Alexander Gerhard (ORCID: https://orcid.org/0000-0002-8071-6062)
- Christopher Robert Butler (ORCID: https://orcid.org/0000-0002-7502-9284)
- Gabriel A. Devenyi (ORCID: https://orcid.org/0000-0002-7766-1187)
- Matthis Synofzik (ORCID: https://orcid.org/0000-0002-2280-7273)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Alexandre de Mendonça (ORCID: https://orcid.org/0000-0002-0488-1453)
- David M. Cash (ORCID: https://orcid.org/0000-0001-7833-616X)
- Isabelle Le Ber (ORCID: https://orcid.org/0000-0002-2508-5181)
- Raquel Sánchez‐Valle (ORCID: https://orcid.org/0000-0001-7750-896X)
- Harro Seelaar (ORCID: https://orcid.org/0000-0003-1989-7527)
- Pietro Tiraboschi (ORCID: https://orcid.org/0000-0002-2171-1720)
- Florence Pasquier (ORCID: https://orcid.org/0000-0001-9880-9788)
- Arabella Bouzigues (ORCID: https://orcid.org/0000-0002-0267-8590)
- Isabel Santana (ORCID: https://orcid.org/0000-0002-8114-9434)
- Lize Corrine Jiskoot (ORCID: https://orcid.org/0000-0002-1120-1858)
- Martina Bocchetta (ORCID: https://orcid.org/0000-0003-1814-5024)
- Lucy Louise Russell (ORCID: https://orcid.org/0000-0001-5023-5893)
- Jonathan D. Rohrer (ORCID: https://orcid.org/0000-0002-6155-8417)
- Markus Otto (ORCID: https://orcid.org/0000-0003-4273-4267)
- Rik R. Vandenberghe (ORCID: https://orcid.org/0000-0001-6237-2502)
- Elizabeth C. Finger (ORCID: https://orcid.org/0000-0003-4461-7427)
- Daniela Galimberti (ORCID: https://orcid.org/0000-0002-9284-5953)
- Paul Best (ORCID: https://orcid.org/0000-0001-6947-8916)
- Mario Masellis (ORCID: https://orcid.org/0000-0002-6244-2096)
- Fermín Moreno (ORCID: https://orcid.org/0000-0001-5200-3164)
- Robert Laforce (ORCID: https://orcid.org/0000-0002-2031-490X)
- Barbara Borroni (ORCID: https://orcid.org/0000-0001-9340-9814)
- Simon Ducharme (ORCID: https://orcid.org/0000-0002-7309-1113)
Institutions
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Neurology
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1212/wnl.0000000000209829
- Citations
- 5
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- McGill University
- EU Joint Programme – Neurodegenerative Disease Research
- National Institute for Health and Care Research
- Department of Health and Social Care
- Deutsche Forschungsgemeinschaft
- Ministero della Salute
- Canada First Research Excellence Fund
- UK Dementia Research Institute
- Canadian Institutes of Health Research
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre