The impact of androgen-induced translation in modulating androgen receptor activity
This study suggests that in HSPC, AR activation triggers a signalling cascade that increases AR protein levels by enhancing its translation rate, thereby amplifying AR activity. However, this mechanism appears to be dysregulated in castration-resistant PCa cells.
Authors
- Jana Scholze
- Matthias Bernhard Stope (ORCID: https://orcid.org/0000-0003-4129-8854)
- Holger H.H. Erb (ORCID: https://orcid.org/0000-0001-5209-7914)
- Sherif Mehralivand (ORCID: https://orcid.org/0000-0003-1405-3683)
- Martin Puhr (ORCID: https://orcid.org/0000-0002-3858-9653)
- Christian Thomas (ORCID: https://orcid.org/0000-0001-6511-965X)
- Laura-Maria Marcelin
- Jörg Hofmann
- Justus Simon Israel
Institutions
- Innsbruck Medical University (AT)
- German Cancer Research Center (DE)
- Universität Innsbruck (AT)
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- Klinik und Poliklinik für Urologie (DE)
- University Hospital Carl Gustav Carus (DE)
- Klinik und Poliklinik für Psychotherapie und Psychosomatik (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Biology Direct
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1186/s13062-024-00550-6
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Astellas Pharma
- Stiftung Hochschulmedizin Dresden