Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma
Our study concludes that sorafenib-induced METs inhibit the ferroptosis of tumor cells, suggesting that targeting the IL4/PADI4/METs axis in HCC could reduce or prevent sorafenib resistance.
Authors
- Jun Lv (ORCID: https://orcid.org/0000-0001-7916-3870)
- Pengfei Zhu (ORCID: https://orcid.org/0000-0003-2141-8636)
- Xiangbo Huang
- Jian Gao
- Nan Yi
Institutions
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1186/s13062-024-00560-4
- Citations
- 11
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- Science and Technology Commission of Shanghai Municipality
- Henan Province Science and Technology Innovation Talent Program
- Henan Medical Science and Technique Foundation