Cervical cancer screening: efficacy of PAX1 and JAM3 methylation assay in the triage of atypical squamous cell of undetermined significance (ASC-US)
PAX1<sup>m</sup>/JAM3<sup>m</sup> testing shows promise as a reliable supplemental method to HPV-DNA testing for the triage of women with cytologic ASC-US. In addition, the molecular triage based on the CISCER assay or single PAX1 or JAM3 methylation, had better effects in the women with non-HPV16/18 group. This approach could potentially minimize overtreatment and unnecessary referrals in clinical practice, enhancing patient management and resource utilization.
Authors
- Xiaoyan Chen (ORCID: https://orcid.org/0000-0002-9098-5493)
- Huafeng Shou
- Pei Liu (ORCID: https://orcid.org/0000-0002-3795-6140)
- Hui Wang (ORCID: https://orcid.org/0000-0001-6789-5185)
- Dongxue Ma (ORCID: https://orcid.org/0000-0003-1140-3676)
- Haifeng Jiang (ORCID: https://orcid.org/0000-0003-3338-4808)
- Linhai Wang (ORCID: https://orcid.org/0000-0002-5537-7898)
- Xuqian Fang
- Hubin Xu (ORCID: https://orcid.org/0009-0009-4509-0250)
Institutions
- Hangzhou Normal University (CN)
- Ruijin Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
- OriginWater (China) (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-11-11
- DOI
- https://doi.org/10.1186/s12885-024-13082-z
- Citations
- 10
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 3.87